Chitosan-Based Nanoparticles for Nucleic Acid Delivery: Technological Aspects, Applications, and Future Perspectives

Chitosan is a naturally occurring polymer derived from the deacetylation of chitin, which an abundant carbohydrate found mainly in shells various marine and terrestrial (micro)organisms. has been extensively used to construct nanoparticles (NPs), are biocompatible, biodegradable, non-toxic, easy prepare, can function as effective drug delivery systems. Moreover, chitosan NPs have employed gene vaccine delivery, well advanced cancer therapy, they also serve new therapeutic tools against viral infections. In this review, we summarize most recent developments field chitosan-based intended nucleic acid vehicles therapy vectors. Special attention given technological aspects complexes for delivery.